EBOO Therapy and Ozone Therapy: Innovative Wellness Solutions in Port Charlotte, Florida
- smacs2000
- Dec 31, 2025
- 4 min read
In the sunny community of Port Charlotte, Florida, where active lifestyles and coastal living are the attraction

, maintaining optimal health is a top priority for many residents. At PCP Health, your dedicated primary care provider in Port Charlotte, we're excited to explore emerging therapies that complement traditional medicine. Two such innovative approaches—EBOO Therapy (Extracorporeal Blood Oxygenation and Ozonation) and Ozone Therapy—have gained attention for their potential in supporting overall wellness, from wound healing to immune function. Backed by peer-reviewed research, these therapies offer promising avenues for those seeking integrative health options. In this blog, we'll dive into what these therapies entail, their benefits, and how they might fit into your health routine right here in Port Charlotte.
Understanding Ozone Therapy
Ozone Therapy involves the medical use of ozone gas (O3), a molecule composed of three oxygen atoms, to promote healing and combat various conditions. It can be administered in multiple ways, such as gaseous applications, ozonated water, or injections, and has been studied for over a century. Its antimicrobial properties make it effective against bacteria, viruses, fungi, and protozoa, while also stimulating oxygen metabolism and activating the immune system. In dentistry and medicine, ozone accelerates blood flow, aids wound healing, and exhibits bactericidal, virucidal, and fungicidal effects.
For Port Charlotte residents dealing with chronic issues like skin conditions or musculoskeletal pain, Ozone Therapy shows potential as a complementary treatment. It has been reviewed for applications in infectious skin diseases, eczema, psoriasis, diabetic foot ulcers, and wound healing, working through antioxidant effects, immunomodulation, and improved microcirculation. Additionally, it may help manage inflammation and pain in conditions such as rheumatoid arthritis, osteoarthritis, and herniated discs. Recent studies even highlight its role in periodontal health, where it disrupts biofilms, modulates inflammation via pathways like Nrf2 and MAPK, and promotes tissue regeneration by upregulating growth factors like VEGF and TGF-β.
Exploring EBOO Therapy
EBOO Therapy takes Ozone Therapy a step further by treating blood outside the body. In this procedure, blood is drawn, exposed to a controlled oxygen-ozone mixture, and then reinfused, allowing for larger volumes to be processed efficiently—up to 4800 ml per hour compared to traditional methods. This interaction generates biomarkers like increased thiobarbituric acid reactants and decreased plasma protein thiols, which help monitor treatment efficacy without significant side effects.
Developed over a decade of research, EBOO has shown clinical promise in conditions like severe peripheral arterial disease, coronary disease, dyslipidemia, and vascular-related deafness. Preliminary human trials indicate therapeutic effects, such as the reduction of lipomas in Madelung disease and improvements in atherosclerotic vasculopathy, with no reported side effects. For those in Port Charlotte facing circulatory or inflammatory challenges, EBOO could represent a safe, innovative option when integrated into a comprehensive care plan.
Benefits and Applications for Dementia and Beyond
While Ozone Therapy and EBOO are versatile, emerging evidence suggests broader applications, including neuroprotective effects. For instance, ozone's antioxidant, anti-inflammatory, and mitochondrial benefits may slow progression in conditions like amyotrophic lateral sclerosis (ALS), with potential relevance to other neurodegenerative diseases. In integrative medicine, ozone helps control pain, infections, inflammation, and wound healing while enhancing quality of life, with no serious adverse effects noted in evidence maps.
Specifically for chronic wounds—a common concern among Florida's aging population—systematic reviews show ozone improves healing rates and closure compared to standard care, possibly via oxidative stress or disinfection. It also holds promise in chemotherapy-induced peripheral neuropathy by modulating oxidative stress and inflammation. These therapies align well with Port Charlotte's focus on holistic health, offering residents non-invasive ways to support immunity, reduce inflammation, and promote recovery.
Integrating These Therapies in Port Charlotte
At PCP Health in Port Charlotte, Florida, we believe in personalized, evidence-based care. While Ozone and EBOO Therapies are supported by research for various benefits, they're most effective as part of an integrative approach. Consult with our experts to see if they suit your needs, especially for wound care, pain management, or circulatory health.
Ready to explore EBOO Therapy or Ozone Therapy in Port Charlotte? Visit www.pcp-health.com or contact our Port Charlotte office today for a consultation. Let's enhance your wellness journey together!
References:
Di Paolo, N., Bocci, V., & Borrelli, E. (2005). Extracorporeal blood oxygenation and ozonation: Clinical and biological implications of ozone therapy. Redox Report, 10(3), 121–130. https://doi.org/10.1179/135100005X38888
Di Paolo, N., Bocci, V., & Di Paolo, M. (2000). Extracorporeal blood oxygenation and ozonation (EBOO) in man: Preliminary report. The International Journal of Artificial Organs, 23(2), 131–141. https://doi.org/10.1177/039139750002300209
Sun, Y., Bedlack, R. L., Barohn, R. J., Baloh, R. H., Bowser, R., Cudkowicz, M. E., ... & Shefner, J. M. (2023). ALSUntangled 68: Ozone therapy. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 24(5-6), 548-552. https://doi.org/10.1080/21678421.2022.2145904
Elvis, A. M., Sabina, K., & Selvin, S. (2011). Ozone therapy: A clinical review. Journal of Natural Science, Biology, and Medicine, 2(1), 66–70. https://doi.org/10.4103/0976-9668.82319
Serra, M. E. G., et al. (2023). The role of ozone treatment as integrative medicine. An evidence and gap map. Frontiers in Public Health, 10, Article 1112296. https://doi.org/10.3389/fpubh.2022.1112296
Fitzpatrick, E., McNab, D., & Norman, G. (2018). Ozone therapy for the treatment of chronic wounds: A systematic review. International Wound Journal, 15(4), 633–644. https://doi.org/10.1111/iwj.12907
El Meligy, O. A., Al-Ansari, A. A., Al-Aali, K. A., Al-Khalifa, K. S., & El-Sayed, K. M. (2023). Ozone therapy in medicine and dentistry: A review of the literature. Dentistry Journal, 11(8), Article 187. https://doi.org/10.3390/dj11080187
Liu, L., Chen, Y., & Li, X. (2023). Ozone therapy for skin diseases: Cellular and molecular mechanisms. International Wound Journal, 20(6), 2376–2385. https://doi.org/10.1111/iwj.14060
Seyam, O., et al. (2018). Clinical utility of ozone therapy for musculoskeletal disorders. Medical Gas Research, 8(3), 103-110. https://doi.org/10.4103/2045-9912.241075
Szklener, K., et al. (2023). Ozone in chemotherapy-induced peripheral neuropathy—Current state of art, possibilities, and perspectives. International Journal of Molecular Sciences, 24(6), 5279. https://doi.org/10.3390/ijms24065279
Hashim, N. T., Babiker, R., Rahman, M. M., Mohamed, R., Priya, S. P., Chaitanya, N. C., Islam, M. S., & Gobara, B. (2025). The impact of ozone on periodontal cell line viability and function. Current Issues in Molecular Biology, 47(2), 72. https://doi.org/10.3390/cimb47020072


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